Dimitrios H. Roukos, MD, PhD, is Professor of Surgery – Precision Cancer Medicine and Founding director of “Centre for Biosystems and Genome Network Medicine†in the Ioannina University, School of Medicine. Following conventional surgical oncology research, he has shifted into interpatient heterogeneity-based Personalized Cancer Medicine combining clinico-pathologic and single gene characteristics. Recently, he is exclusively focusing on intratumor multi-regional and even single-cell genetic, genomic, transcriptional and regulatory network heterogeneity-based drug resistance and relapse towards future clinical Precision Oncology. He has developed and published 3 breakthrough concepts to overcome clinical unmet needs. He has published > 240 PubMed papers, 36 on Precision Medicine and Oncology, and 80 on static and spatiotemporal genome analysis with NGS. These publications have received more than 9000 citations with h-index: 75 (Scopus). He is reviewer in many high impact journals including some with impact factor (IF) >30, evaluator in innovative research projects (EU, France, Italy, Belgium, Luxemburg, Poland), member in the editorial board of 25 international journals with IF, as well as Organizing Committee member and Invited lectures in > 130 International Conferences.