Experts Meeting on Cancer Medicine, Radiology & Treatment June 29-30, 2020 Athens, Greece

Biography:

Jana Slobodnikova. M.D., end study on Charles University in Prague., gradued - CSc / PhD / completed at the age 38 years from Institus of Experimental Oncology Slovac Scientic Academy. Ass. Prof. in 43 years from Trnaviensis University, Prof. emeritus at age 45 years from St. Elizabeth High Scool. I have lectured at several universities - Prague, Tren?ín, Trnava and Bratislava. I am the author of teaching script, university textbooks, I lead workshops, I organize international congresses and worksops Her has published more than 90 scientific papers, from then 25 papers in renomed journals and has been serving as an 5 editorial board member of repute. Her has published 3 monography, Her founded the Section of Breast Imaging in 1996, from 1996 her is president The Section of Breast Imaging of Slovak radiologic Society and vice president The Slovak Society of Ultrasound in Medicine. Membership in organizations : ECR, EUSOBI, EFSUMB , SSUM ( Slovak Society of Ultrasound in Medicine ) and SRS ( Slovak Radiology Society).

Abstract:

Breast cancer is the most common malignant disease in women worldwide. We compare the results of digital  breast  tomosynthesis  ( DBT – digital 3D mamography , new technics methody with x- ray examinations ) ) as a screening and sonography   (US) method, as a complementary method to mammography.

Objective: To compare the data obtained in the US and DBT within a retrospective study of women with histologically confirmed breast cancer.

Material and methods : We processed retrospective data of 916 patients examined at the Clinic of Radiology from 25 December 2015 to 31 January 2019. The age of patients was from 29 years to 86 years, median 53 years. Biopsy following DBT was indicated in 357 cases. Of these, 78 were positive, others were benign. In the group of malignant lesions, we compared the findings with the DBT. We evaluated lesions size, morphological character, vascularization, number of deposits, changes in gland architecture, number and presence of microcalcifications and changes in lymph node.   In our retrospective study, we aimed to verify the cross-compliance and equivalence of results obtained by the two imaging techniques. We evaluated the data using MC Nemar's test using paired tests (parametric t-test and non-parametric Wilcoxon test). We have tested the relationship with Spearman's correlation coefficient

Results : The results are completed in the tables. The following results came from the comparison: Significant disagreement exists in visualization of vascularization, microcalcifications, even sizes, where e.g. DBT shows higher values, the methods also differ when comparing lesions by patient age. At age over 50 years, DBT is more accurate, compared to US at age 50 years. The low correlation of correspondence is also in the field of architectural changes. More accurate is the US.

Discussion: The disagreements of both methods are significant. And in all the retrospective study parameters. In women over 50 years of age, metastatic mammography is more accurate in the area of microcalcifications and changes in the area of lesions, bearing shapes are less suspect, and interstitial architecture is less convincing compared to US examinations. Women of younger age benefit from US, a combination of both modalities is essential. Both DBT and US are a complementary method to the golden standard of breast cancer screening - digital X-ray mammography. For suspicious and ambiguous images, both methods must be added, combined.

Conclusion: All statistical tests show that there are significant differences between the US and DBT methods in image processing of the same patient, and we can not accept the consistency of their imaging. We must accept their supplementation, combination.

Key words: breast cancer, sonography, digital breast tomography, correlation

Biography:

Abstract:

Background:

For Siewert  type I and II gastroesophageal junction tumor (GEJ) laparoscopic proximal gastrectomy can be performed. It is associated with several perioperative benefits compared with open proximal gastrectomy. The use of laparoscopic proximal gastrectomy (LPG) has become an increasingly popular approach for select tumors

Methods

We describe our technique for  LPG, including the preoperative work-up, illustrated images of the main principle  steps of the surgery, and our postoperative course.

Results

Thirteen pts (nine male, four female) with type I ,II  (GEJ) adenocarcinoma had laparoscopic radical proximal gastrectomy and D2 lymphadenectomy . All of our patient received neoadjuvant chemotherapy, eleven patients had intrathoracic anastomosis through mini thoracotomy ( two hand sewn end to end anastomoses and the other 9 patient end to side  using circular stapler), two patients with intrathoracic anastomosis had flap and wrap technique, two patients had thoracoscopic esophageal and mediastinal lymph node  dissection with cervical anastomosis

The mean blood loss 80ml, No cases was converted to open .The mean operative time  250 minute Average LN retrieved 19-25, No sever complication such as leakage, stenosis, pancreatic fistula ,or intra-abdominal abscess were reported. Only One patient presented with empyema 1.5 month after discharge that was managed conservatively.

Conclusion

For carefully selected patients, LPG in GEJ tumour type I nad II  is a safe  and reasonable alternative for open technique , which is associated with similar oncologic outcomes and low morbidity. It showed less blood loss, respiratory infections, with similar 1- and 3-year survival rates.

Biography:

Abstract:

The purpose of hospital tumor boards (TBs) is for physicians to incorporate evidenced-based clinical guidelines and multidisciplinary perspectives to find the best treatment program for patients; however, team-based dynamics can influence the decision-making process and outcome. This qualitative ethnographic study investigated team-based mechanisms to review the influence of collaboration on cancer treatment decision-making. This study focused on the identification and theoretical explanation of collaborative organizational structures, their presence in multidisciplinary tumor boards, and their effect on cancer treatment decision-making within the groups. The research is grounded in organizational theories that have historical prominence in group decision-making, social hierarchy, and interdisciplinary collaboration; it uses an ethnographic research methodology to ground these theories with the findings of the research to best illustrate and explain the phenomenon under investigation. Tumor board observation and interview data were gathered over three years at seven research hospitals in the United States and United Kingdom (44 tumor boards). Results showed an interdisciplinary collaborative culture exists in some tumor boards influencing treatment decision-making processes and outcomes. This study contributes to the current knowledge of cancer treatment by expanding upon prior findings through multihospital and multi-tumor board field research conducted in both the United Kingdom and United States.

Biography:

DR Jehad Zweiri, lecturer in Cancer studies at the University of Liverpool Medical School, born and grew up in Jordan and received his Bachelor’s degree from the University of Jordan. He obtained his master degree from London School of Hygiene and Tropical Medicine/University of London, and then obtained his PhD degree in 2000 from Kings College Medical School/University of London, in the field of Immune Gene Therapy of Cancer under the supervision of Professor Farzin Farzaneh. He then started his work as Postdoctoral Associate at the department of Immunology and Medicine at the University of Liverpool in 2002. In 2010 he was appointed as a lecturer in the University of Liverpool Medical School and he is currently fellow of the British Higher Education Academy since 2012.

Abstract:

Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used in some studies to compare the in vitro and in vivo efficacy of autologous vs allogeneic tumour cell vaccines. This study examines the effect of g-irradiation on a range of tumor cell lines in conjunction with suicide gene therapy of cancer. To determine the efficacy of this modality, a series of in vitro and in vivo experiments were conducted using genetically modified and unmodified tumor cell lines. Following co-culture of HSV-TK modified tumor cells and unmodified tumor cells both in vitro and in vivo we observed that the PA-STK ovarian tumor cells were sensitive to g-irradiation, completely abolishing their ability to induce bystander killing of unmodified tumor cells. In contrast, TK-modified human and mouse mesothelioma cells were found to retain their in vitro and in vivo bystander killing effect after g-irradiation. Characterisation of tumor cell death showed that PA-STK cells underwent pyknosis (necrosis) after g-irradiation. These results suggest that PA-STK cells are not suitable for clinical application of suicide gene therapy of cancer, as lethal g-irradiation (100Gy) interferes with their bystander killing activity. However, the human mesothelioma cell line CRL-5830-TK retained its bystander killing potential after exposure to similarly lethal g-irradiation (100Gy). CRL-5830 may therefore be a suitable vehicle for HSV-TK suicide gene therapy. This study highlights the diversity among tumor cell lines and the careful considerations needed to find the optimal tumor cell line for this type of whole cell tumour vaccination.

Biography:

Dr. Kakil Ibrahim Rasul has completed his Bachelor of Medicine, Bachelor of Surgery (MBchB) from the College of Medicine, University of Mosul in 1978. He completed his Certificate of Arab Board for Medical Specialization in Baghdad, Iraq in 1989,  MRCP (UK), Royal College of Physicians and Surgeon of Glasgow (U.K) in 2000 , FRCP Edin (UK) Royal College of Physician, Edinburgh of Glasgow (U.K) in 2004 and has been granted an ESMO Certificate (European Society for Medical Oncology) in 2004 and recertified in 2009. He is a Senior Consultant in Haem/ Oncology in the National Center for Cancer Care and Research in Hamad Medical Corporation, Doha, Qatar and an Associate Professor in Clinical Medicine at Weil Cornell Medical College in Qatar. He leads the Hepatobiliary Pancreatic Multidisciplinary Team and a core member of the Gastrointestinal Multidisciplinary Team, Hamad Medical Corporation. He is also an active member of ESMO and ASCO, a core member of both Colorectal and Hepatobiliary MENA-NCCN guidelines panels tasked to modify and develop guidelines.

Abstract:

Hepatocellular carcinoma (HCC) has a unique geographic distribution that is likely to be determined by specific etiologic factors. There is a distinctive difference in sex and age related occurrence of disease. In the Gulf region, there are contradicting data on the prevalence and death rates due to HCC. In this review we highlight some aspects of HCC specific to the Gulf region. A retrospective analysis of 150 patient’s data is presented, including demographic, epidemiological, aetiological disease status assessment with child Pugh criteria, modes of treatment and treatment related outcome. Hepatitis C virus (HCV) infection was the most common (45%) documented etiology, similar to Western European countries, followed by hepatitis B virus (HBV) infection in 27% of cases, alcoholic liver disease only in six patients (4%). Child-Pugh assessment was A in 33%, B in 37% and C in 30% of observed patients. Surgery (liver resection or transplantation) was performed in 12% and local ablation in 5% of cases. The others were treated by chemo-embolization in 17% and by systemic therapy with sorafenib in 13% of patients. Nearly half of the patients (53%) were in advanced stages and received palliative treatment. To improve the outcome of treatment in HCC patients in the Gulf region, an effective and strategic screening program must be implemented for early diagnosis and treatment to improve the outcome of this mostly fatal disease.

Biography:

Dr. Kakil Ibrahim Rasul has completed his Bachelor of Medicine, Bachelor of Surgery (MBchB) from the College of Medicine, University of Mosul in 1978. He completed his Certificate of Arab Board for Medical Specialization in Baghdad, Iraq in 1989,  MRCP (UK), Royal College of Physicians and Surgeon of Glasgow (U.K) in 2000 , FRCP Edin (UK) Royal College of Physician, Edinburgh of Glasgow (U.K) in 2004 and has been granted an ESMO Certificate (European Society for Medical Oncology) in 2004 and recertified in 2009. He is a Senior Consultant in Haem/ Oncology in the National Center for Cancer Care and Research in Hamad Medical Corporation, Doha, Qatar and an Associate Professor in Clinical Medicine at Weil Cornell Medical College in Qatar. He leads the Hepatobiliary Pancreatic Multidisciplinary Team and a core member of the Gastrointestinal Multidisciplinary Team, Hamad Medical Corporation. He is also an active member of ESMO and ASCO, a core member of both Colorectal and Hepatobiliary MENA-NCCN guidelines panels tasked to modify and develop guidelines.

Abstract:

A form of genomic instability, occurs through the insertion or deletion of repeating nucleotides during DNA replication and failure of the mismatch repair system to correct errors in nucleotide repeat markers, patients with functional MMR mechanisms are MSS or pMMR About 15% of all CRCs have dMMR activity this is due to inactivating “events” to one of several DNA MMR genes MSH2 and MLH1 (the “major” DNA MMR genes )MSH6 and PMS2 (the “minor” DNA MMR genes) dMMR) in CRC is manifested either by MSI ,  a PCR-based test for mutated microsatellite sequences on DNA extracted from tumor. Abnormal IHC, with absent expression of the involved MMR proteins Both tests can be done on surgical specimen or biopsies of neoplastic lesions, Both tests are stable for decades in paraffin MSI testing by PCR is more sensitive than IHC (~ 99% vs ~ 90-95%), but IHC is easier to obtain. This marker is important for the immunotherapy selection in metastatic CRC. Will have review of the markers with clinical studies clarifying the clinical implications of this biomarkers and cases from real life from my institute.

Biography:

Dr. Sudha Bansode is a Associate Professor in Zoology at Shankarrao Mohite College, Akluj, Maharashtra State, India. Recently she has completed her Post Doctoral Studies at University of California, Riverside, USA. She is a active researcher & passionate teacher in India. Still she has been published above 25 research papers in International Journals & she is interested on Bone Research. Also she has honor of Distinguished Editorial Board Member of several International Journals. She is a own author of “Textbook Histological Techniques” & “Outlines of Physiology”. And now she is working on another own reference book “Rhythms in Freshwater Crustaceans”. She is a University recognized research guide for Ph.D. students in India. She was a invited Indian Speaker of “OXFORD SYMPOSIUM” on 27-29 August, 2014 at Balliol College, Oxford, United Kingdom & CELL SIGNALING & CANCER THERAPY – International Conference at Double Tree, Hilton Chicago on 27-28 September 2017. She was academic visitor of Bangkok- Thailand, Colombo-Sri Lanka, Daira-Dubai-UAE. Her recent intellectual Interaction is with many International Professional groups.

Abstract:

Biomarkers are molecules that indicate normal or abnormal process taking place in your body and may be a sign of an underlying condition or disease. Various types of molecules, such as DNA (genes), proteins or hormones, can serve as biomarkers, since they all indicate something about your health. A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition. The term is also occasionally used to refer to a substance whose detection indicates the presence of a living organism. Biomarkers are often measured and evaluated to examine normal biological processes, Biomarkers are distinct biological indicators (cellular, biochemical or molecular) of a process, event or condition that can be measured reliably in tissues, cells or fluids, and can be used to detect early changes in a patient's health. Some examples of biomarker include blood cholesterol a well-known biomarker of risk for, Biomarker is short for biological marker, and is used as an indication that a biological process in the body has happened or is ongoing. While some biomarkers are used to show that the body has been exposed to a chemical toxin or other environmental impact - most associate biomarkers with medicine.
        A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. NIH Biomarkers Definitions Working Group: "A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." World Health Organization: "Any substance, structure, or process that. Biomarkers are characteristics of the body that you can measure. So your blood pressure is actually a biomarker. Biomarkers are very important to medicine in general. We're all used to going to the doctor and getting all our test results, right, and even imaging x-ray results or CAT scans.

Biography:

Presented papers at various International conferences including ALL INDIA INSTITUTE OF MEDICALL SCIENCES New Delhi 2009 and 2012 for their conferences on Gerontology and Geriatric Medicine and WORLD ALLERGY ORGANISATION  OF US for their  conferences on Allergy, Asthma and Immunology 2010 and 2012, National conferences on pulmonary diseases at Bhubaneswar and Chennai, Indo Global Health  Care summit and Expo , International conference in  2014 at Hyderabad.  He has been given award  for  Excellence in  Health Care by the Organizers of the International conference.    He has also presented paper at AIIMS New Delhi, for their International conference on Multidisciplinary Health Care 2014 and 2016 and many others as  stated below:

He has presented papers at international cancer conferences ,  Indo global cancer therapy conference at Hyderabad and Global cancer conference at Bengalore November 2015, International conference on Radiation Oncology and Anti-Cancer Therapy , at Dubai in the year 2016 November 21^st and 22^nd , In addition to the above, he has presented papers   ( Video presentations ) at  25^th World Congress on CANCER SCIENCE AND THERAPY and 10^th World Congress   on  BIOMARKERS & CLINICAL   RESEARCH Conference at Baltimore  USA  18^th – 20  October 2017,  INNOVATE CANCER THERAPY  conference at Brisbane  , Australia , 29^th 30^th November, 2017 .  His has been taken as an Advisory Board  Member.

He  has devised exercises by which the excess mucus ( Hyper Secretion of Mucus ) , a major  pathological feature of Airway  diseases  formed  as a result of Inflammation  and  responsible  for  various  respiratory  diseases,  can be drained out within minutes  from upper airway passages mouth, nose and pharynx,  the primary sites of colonization of pathogens ,  the sinuses, the weigh stations to the brain and the traceo bronchial tree  resulting  in normal breathing.

Abstract:

The objective of the paper is to create awareness among people about alternative and complimentary methods to protect themselves from various respiratory diseases including Throat and Lung cancers.  The diseases cause the following changes in Airways. 1) Inflammation: Acute inflammation is a defense process whereas chronic inflammation is a disease process.  2) Hyper secretion of mucus:  is the result of goblet cell hyperplasia in respiratory mucosa and is a prominent future of inflammation. They go together. Chronic mucus hyper secretion is a potential risk factor for an accelerated loss of lung function. The thick viscous mucus in the lungs will be conducive to pathogens. Currently available medicines and methods are not able to meet the needs of the sufferers. Continued inflammation and mucus hyper secretion may significantly contribute to transformation of normal cells into cancer cells i.e. the scope for series of mutations on Genes may get increased. 3) Bronchospasm: is an additional factor in asthma patients.

Methods: Exercise is a potent medication in history.  It can be used as a tool to manage various respiratory diseases including throat and lung cancers. a)  Cleaning Upper airway passages, mouth, nose and pharynx, the primary sites of colonization of pathogens and the sinuses, the way stations to the brain. These exercises should be practiced with hypertonic solution i.e., a solution having greater osmotic pressure than that of cells or body fluids and draws water out of cells thus inducing plasmolysis. b) Physical, aerobic and yogic exercises: help in strengthening the Inspiratory and Expiratory muscles.

Conclusions: Any mucus related respiratory health problem commences from upper airway passages and spread to tracheo bronchial tree as they constitute only one path way. The mucociliary clearance mechanism becomes defunct when excess and sticky mucus forms. Once the upper airway passages are cleaned of it, the defunct cilia become active and ciliate mucus towards mouth and it can be pushed out easily. The upper airway passages and the bronchial airways get cleaned from excess and sticky mucus.  The diseases originating from its pathway come under control. The exercises are based on the concept “ Once the offending factor, excess mucus is removed, the origin of it, Inflammation  gets resolved “ As a result of management of the above two  factors,  the gene damaging effect may get  reduced i.e., the scope for  series of  mutations  on genes  may get reduced.

Biography:

Mr. Muhammad Usman, Former Director General of Agricultural Research System, Government of Pakistan who retired from service after a spotless career of about 32 years with senior level experience on research and development of integrated agricultural production, industries, biotechnology and bioenergy on a sustainable way. Mr. Usman is basically an agricultural scientist with specialization of agricultural, food and biochemistry working on the yield and quality of various products and published several research papers. Mr. Usman is consider as the senior most scientist in the world, always participated in the international conferences as a plenary, keynote, renowned speaker, organizing committee member as well as moderator of the conferences around the world. Mr. Usman established “Prominent Agro Based Industries, Agro Based Industries and Consultancy SDN BHD” in Malaysia and “Foundation for Rural Development in Pakistan”, with primarily aims to work on integrated agricultural project for Rural Development through improvement in agriculture and consultancy services to the formers at Malaysia.

Abstract:

The aims of presentation consist of oncology, health, employment, income, crises, life and cancer were studied and reported that Cancer Medicine, Radiology and treatment is the major tools for the development of health basic need of daily life as well as to control the different types of cancer diseases in the world.   The study reported that the word oncology consist of two parts i.e “onco” means bulk, mass, or tumor while “logy” means study. Therefore oncology is known is the study of tumors or cancer. In other words, oncology means the branch of science that deals with the tumor and cancer. The study also reported that oncology is the study of cancer and it treatment in medical science. The study further reported that cancer is a group of more than 100 different disease. In other words that cancer is a very serious disease which can developed almost anywhere in the body. The most important oncology diagnostic remains the clinical history of the patient, common symptoms that point towards cancer include fatigue, weight loss, unexplained anemia, fever of unknown origin etc. Oncology depends on diagnostic tools like biopsy or removal of bits of the tumors tissue and examining it under the microscope. Other diagnostic tools include endoscopy for the gastrointestinal tract, imaging studies like X-rays, CT scanning, MRI scanning, ultrasound and other radiological techniques, Scintigraphy, Single Photon Emission Computed Tomography, Positron emission tomography and nuclear medicine techniques etc. The oncologist’s role including explaining the cancer diagnosis and stage to the patient. Radiology is the medical discipline that uses medical imaging to diagnose and treat diseases within the bodies of both humans and animals. In other words, Radiology is a medical specialty that uses imaging to diagnose and treat diseases seen within the body. ... Find out more about radiology techniques. Interventional radiology is the performance of (usually minimally invasive) medical procedures with the guidance of imaging technologies. In other words the science dealing with X-rays and other high-energy radiation, especially the use of such radiation for the diagnosis and treatment of disease. the light of the above study, it is proposed to commercialize the Oncology and Cancer Science is the major tools for the development of health basic need of daily life as well as to control the different types of cancer diseases in the world.

Biography:

Abstract: